金立波
邮箱:20160121@wzu.edu.cn 电话:18757713755
博士,温州大学生命科学研究院 常务副院长、温州市生物医药协同创新中心主任。曾先后在吉林农业大学科研处、生物反应器与药物开发教育部工程研究中心、生命科学学院、温州市生物医药协同创新中心等多部门任职。2016年8月,入职温州大学,任常务副院长并主持工作;带领教职工申请并成功获批温州市生物医药协同创新中心、“浙江省生物医药协同创新中心、生长因子药物开发浙江省工程研究中心”等省市级科研平台3项,教育部省部共建生物医药协同创新中心1项。组建了生物反应器研究与药物开发的研究团队,建立了药学、医学与生物医用材料等多学科相融合的科研模式。主要科研方向涉及生物医用材料、生长因子基础理论研究、生物药物研究与开发等,先后在life sciences、Pharmaceutics、Theranostics、Apoptosis、Materials Science & Engineering C、royal society of chemistry biomaterials-science、Frontiers in Genetics等国内外学术刊物上发表论文40篇(累计IF>150),其中第一/通讯作者论文27篇(累计IF>110);申报专利40余项,获授权26项;参与科研项目10余项,平台建设项目7项,获吉林省技术发明一等奖1项,长春市科技进步奖1项,指导学生参加浙江省互联网+、挑战杯竞赛均获得省级银奖,全国第八届互联网+创新创业大赛,铜奖。
近五年主要科研成果:
一、期刊论文(一作及通讯作者)
(1)Chen H#, Lei P#, Ji H#, Yang Q, Peng B, Ma J, Fang Y, Qu L, Li H, Wu W*, Jin L*, Sun D*. Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies. Mater Today Bio. 2023 Jan 6;18:100543. doi: 10.1016/j.mtbio.2023.100543. PMID: 36647536; PMCID: PMC9840185. (IF:10.761)
(2)Li Y#, Liu Y#, Jin L*, Peng R*. Crosstalk between Ca2+ and Other Regulators Assists Plants in Responding to Abiotic Stress. Plants (Basel). 2022 May 19;11(10):1351. doi: 10.3390/plants11101351. PMID: 35631776; PMCID: PMC9148064. (IF:4.658)
(3)Fang Y, Ma J, Lei P, Wang L, Qu J, Zhao J, Liu F, Yan X, Wu W, Jin L, Ji H*, Sun D*. Konjac Glucomannan: An Emerging Specialty Medical Food to Aid in the Treatment of Type 2 Diabetes Mellitus. Foods. 2023 Jan 12;12(2):363. doi: 10.3390/foods12020363. PMID: 36673456; PMCID: PMC9858196. (IF:5.561)
(4)Liu F, Qu L, Li H, He J, Wang L, Fang Y, Yan X, Yang Q, Peng B, Wu W, Jin L*, Sun D*. Advances in Biomedical Functions of Natural Whitening Substances in the Treatment of Skin Pigmentation Diseases. Pharmaceutics. 2022 Oct 27;14(11):2308. doi: 10.3390/pharmaceutics14112308. PMID: 36365128; PMCID: PMC9697978. (IF:6.525)
(5)Lei P#, Chen H#, Ma J#, Fang Y, Qu L, Yang Q, Peng B, Zhang X, Jin L*, Sun D*. Research progress on extraction technology and biomedical function of natural sugar substitutes. Front Nutr. 2022 Aug 3;9:952147. doi: 10.3389/fnut.2022.952147. PMID: 36034890; PMCID: PMC9414081. (IF:6.590)
(6)Jiahui Ma#,Ling Yong#,Pengyu Lei#,Hua Li,Yimeng Fang,Lei Wang,Haojie Chen,Qi Zhou,Wei Wu,Libo Jin*, Da Sun*, Xingxing Zhang* .Advances in microRNA from adipose-derived mesenchymal stem cells-derived exosome: focusing on wound healing. Journal of Materials Chemistry B .DOI: 10.1039/D2TB01987F (IF:7.571)
(7)Jin L*, Wang Y, Liu X, Peng R, Lin S, Sun D, Ji H, Wang L, Zhang Y, Ahmad N. Codon optimization of chicken β Gallinacin-3 gene results in constitutive expression and enhanced antimicrobial activity in transgenic Medicago sativa L. Gene. 2022 Aug 15;835:146656. doi: 10.1016/j.gene.2022.146656. Epub 2022 Jun 6. PMID: 35680025. (IF:3.913)
(8)Yinai Liu,#Qianqian Chen,# Yaoqi Li, Liuliu Bi, Sue Lin, Hao Ji, Da Sun, Libo Jin*, Renyi Peng*.Hydrogen sulfide-induced oxidative stress mediated apoptosis via mitochondria pathway in embryo-larval stages of zebrafish,Ecotoxicology and Environmental Safety,Volume 239,2022,113666,ISSN 0147-6513, (IF:6.291)
(9)Lei Wang,Jiahui Ma,Wei Wu,Yimeng Fang,Fan Liu,Qinsi Yang,Xiang Hu,Xujiang Gu,Zhiying He,Da Sun*,Libo Jin*,Xingxing Zhang*.Effect of aerobic exercise as a treatment on type 2 diabetes mellitus with depression-like behavior zebrafish.life sciences. Volume 300,2022,120578,ISSN 0024-3205,https://doi.org/10.1016/j.lfs.2022.120578. (IF:5.037),
(10)Yaoqi Li,#Da Sun,#Ke Xu*,Libo Jin*,Renyi Peng*. Hydrogen Sulfide Enhances Plant Tolerance to Waterlogging Stress. Plants (Basel). 2021 Sep 16;10(9):1928. doi: 10.3390/plants10091928. PMID: 34579462; PMCID: PMC8468677.(IF:3.935)
(11)Yaoqi Li,#Qianqian Chen,# Yinai Liu, Liuliu Bi,Libo Jin*,Ke Xu*,Renyi Peng*.High glucose‑induced ROS‑accumulation in embryo‑larval stages of zebrafish leads to mitochondria‑mediated apoptosis. Apoptosis, (2022.5.21). https://doi.org/10.1007/s10495-022-01731-2 (IF:4.677)
(12)Haojie Chen#,Hao Ji#,Xiangjun Kong,Pengyu Lei,Qinsi Yang,Wei Wu,Libo Jin*, Da Sun*. Bacterial Ghosts-Based Vaccine and Drug Delivery Systems. Pharmaceutics 2021.11.8, 13(11), 1892. (IF:6.525)
(13)Nguyen Quoc Viet Hoang, Kong Jie, Naveed Ahmad, Ma Xintong, Zhang Xinyue, Wu Yuhang , Wang Nan, Yao Na, Liu Xiuming, Jin Libo*.Genome-wide identification and expression profiling of flavonoid 3'-hydroxylase gene family in Carthamus tinctorius L.中科院III区,Notulae Botanicae Horti Agrobotanici Cluj-Napoca,2021.11.Volume 49,Issue 4. (12509)(IF:1.444)
(14)Chen Q#, Ji H#, Lin Y, Chen Z, Liu Y, Jin L*, Peng R*. LncRNAs regulate ferroptosis to affect diabetes and its complications. Front Physiol. 2022 Sep 26;13:993904. doi: 10.3389/fphys.2022.993904. PMID: 36225311; PMCID: PMC9548856. (IF:4.755)
(15)Sun Fan,# Naveed Ahmad,# Jin Libo,# Zhang xinyue, Ma Xintong, Nguyen Q. V. HOANG, Ali I. MALLANO, Wang Nan, Yang Zhuoda, Liu Xiuming, Yao Na.Genome-wide investigation of Hydroxycinnamoyl CoA: Shikimate Hydroxycinnamoyl Transferase (HCT) gene family in Carthamus tinctorius L中科院III区,Notulae Botanicae Horti Agrobotanici Cluj-Napoca,2021.09.27.Volume 49,Issue 3. (12489)(IF:1.444)
(16)Libo Jin,# Guoming Zeng,# Haojie Chen,Lei Wang,Hao Ji,Sue Lin,Renyi Peng,Da Sun*.Mechanism of lignin degradation via white rot fungi explored using spectral analysis and gas chromatography-mass spectrometry.BioResources. 2021.06.15;Vol16, Issue,5494—5507;(IF:1.614)
(17)Yu-Qing Yan,#Li-bo Jin,#Yu Wang,Song-Yan Lu,Yi-Feng Pei,Dong-Wei Zhu,Fu-Sheng Pang,Hao Dong*,Gui-Xue Hu. Goose parvovirus and the protein NS1 induce apoptosis through the AIF-mitochondrial pathway in goose embryo fibroblasts. Research in Veterinary Science, 2021,4.22.vol137,(2021), 68-76(IF:2.534)
(18)Da Sun,Jia Chen,Yuan Wang,Hao Ji,Renyi Peng,Libo Jin*,Wei Wu*.Advances in refunctionalization oferythrocyte-based nanomedicinefor enhancingcancer-targeteddrugdelivery. Theranostics,2019.09.21;Vol. 9, Issue 23,6885—6900;(IF:11.556)
(19)Jing Zhang,Wenhe Zhu,Benkai Xin,Sue Lin,Libo Jin*and Huiyan Wang*. Development of an antibacterial surface with self-defensive and pH-responsive function.royal society of chemistry biomaterials-science, 2019.06.12;2019(9),3795—3800;(IF:5.251)
(20)Libo Jin,Jin Wu,Saverio Bellusci*,Jin-San Zhang*;Fibroblast Growth Factor 10 and Vertebrate Limb Development;Frontiers in Genetics; 2019.01.07,9,(705),1-9;(IF:4.15)
(21)Libo Jin,Jia Chen,Xiaoqing Yan,Chi Zhang,haishan Tian,hao Ji,Lin sue,RenYi Peng,Da sun*.Tripterygium wilfordii polyglycosides inhibit TGF-BETA 1/NF-Kappa B signaling pathway and improve renal fibrosis in diabetic nephropathy.Acta Medica Mediterranea,2019.02.20;(35),2787—2791; (IF:0.835)
(22)Guoming Zeng,#Libo Jin,#Qinsi Ying, Haojie Chen,Murinda Charmaine Thembinkosi,ChunguangYang,Jinlong Zhao, Hao Ji,Sue Lin,Renyi Peng,Maolan Zhang,Da Sun;Regulatory T Cells in Cancer Immunotherapy:Basic Research Outcomes and Clinical Directions.Cancer Management and Research,2020:12,10411-10421(IF:2.886)
(23)Libo Jin,Yunpeng Wang,Nuo Xu,Dezhong Wang,Xiuming Liu,Renyi Peng,Chao Jiang,Xiaokun Li*;Expression and activity analysis of β Gallinacin-3 in Arabidopsis.Protein expression and purication,2018.04,(144),1-4; (IF:1.42)
(24)Renyi Peng#,Hao Ji#,Libo Jin#,Sue Lin,Yijiang Huang,Ke Xu,Qinsi Yang,Da Sun*and Wei Wu*;Macrophage-Based Therapies for Atherosclerosis Management.Journal of Immunology Research.2020.01.29,2020,1-11.(IF:3.327)
(25)Da Sun,Jia Chen,Wei Wu,Ju Tang,Li Luo,Kun Zhang ,Libo Jin, Sue Lin,Yitian Gao,Xiaoqing Yan,Chi Zhang. MiR-802 causes nephropathy by suppressing NF-κB-repressing factor in obese mice and human.Journal of Cellular and Molecular Medicine. 2019.02.07,23(4),2863—2871; (IF:4.658)
(26)Sue Lin,Yingjing Miao,Shiwen Su,Jian Xu,Libo Jin,Da Sun,Renyi Peng,Li Huang,Jiashu Cao. Comprehensive analysis of Ogura cytoplasmic male sterility-related genes in turnip (Brassicarapa ssp. rapifera) using RNA sequencing analysis and bioinformatics.Plos One,2019.06.14,14(6),1—29; (IF:2.806)
(27)HaoJi*,KeXu,XiamengDong,DaSun,RenyiPeng,SueLin,KailunZhang,LiboJin;Transcriptional profiling reveals molecular basis and the role of arginine in response to low-pH stress in Pichia kudriavzevii.Journal of Bioscience and Bioengineering.2020.12,130(6),588-595.(IF:2.366)
(28)Sue Lin*,Shiwen Su,Libo Jin,Renyi Peng,Da Sun,Hao Ji,Youjian Yu,Jian Xu*;Identification of microRNAs and their targets in inflorescences of an Ogura-type cytoplasmic male-sterile line and its maintainer fertile line of turnip (Brassica rapa ssp. rapifera) via high-throughput sequencing and degradome analysis.Plos One,2020.7.30,(IF:2.806)
二、授权专利:
1、发明专利:
1) 一种肥胖性II型糖尿病斑马鱼模型的构建方法及应用;202110667786.2(已授权)
2) 一种构建糖尿病型斑马鱼模型的方法;202110297218.8(已授权)
3) 一种适用于糖尿病足使用抗菌面料的制备方法;202110321075X(已授权)
4) 抗菌载药纱布的制备方法及糖尿病足患者用足套;202010640897X(已授权)
5) 一种人源角质细胞生长因子2的基因序列、表达载体及生产方法;201711441853.92(已授权)
6) 基于药用植物来源的粉末和药机,2019100396638.9(已授权)
7) 手术刀清洗装置;201910014373.7;(已授权)
8) 小型药用植物材料粉碎机,201910065785.3 (已授权)
9) 一种弧度高度可调的扁平足矫正鞋垫,申请号:2020107698452(已授权)
10) 抗菌载药纱布的制备方法及糖尿病足患者用足套, 202010640897X(已授权)
11) 一种糖尿病足专用高透气纱布的制备方法, 2020106415437(已授权)
12) 抑制库德毕赤酵母菌株细胞聚集的方法、构建和应用, 2020105222282(已授权)
2、实用新型:
13) 一种新型医学检验管 201821243667.X(已授权)
14) 一种便携式医学检验箱 201821243526.8 (已授权)
15) 一种中药材烘干装置;201822083503.6;(已授权)
16) 蛋白药物临实验医用箱;201920110142.1;(已授权)
17) 医用棉签卷棉机;201920053482.5;(已授权)
18) 康复行走训练医用拐杖;201822169717.5;(已授权)
19) 一种斑马鱼有氧运动实验装置;2021228817540(已授权)
20) 一种具有交换磁场功能的保健鞋;2021213879050(已授权)
21) 一种斑马鱼养殖用过滤装置;202121396000X(已授权)
22) 一种斑马鱼养殖用多功能观察系统;202121396032X(已授权)
23) 一种用于斑马鱼养殖观察的养殖的净化装置;2021213974375(已授权)
24) 一种斑马鱼养殖用供水装置;2021213957350(已授权)
25) 一种斑马鱼养殖用定时投食装置;2021213957740(已授权)
26) 一种空气过滤结构层、空气净化器、口罩;2020202792330(已授权)
三、近年主要参与科研项目
1、温州市,利用食用型白腐真菌进行水体控藻的研究;20万,第2
2、温州市,番鸭细小病毒非结构蛋白NS2诱导鸭胚成纤维细胞凋亡的分子机制研究,6万,主持
3、浙江省,转录因子组合诱导人在纤维细胞重编程为leydig-like细胞及其应用研究,10万第2
4、温州市,生物质耦合白腐菌强化治理蓝藻水华代谢损伤机制及生物毒理性研究,3万,第2
5、温州市,一氧化氮(NO)提升水涝灾害后玉米幼苗成活率的研究,3万,第2
6、温州市,科协博士创新工作站(温州鸥肽医学检验实验室有限公司),主持
7、横向课题:线粒体损伤与免疫性疾病相关检测指标研究 ( 25万)主持
四、平台项目
1、浙江省级平台项目:浙江省生物医药协同创新中心,配套500万(实际负责人)
2、浙江省级平台项目:生长因子药物开发浙江省工程实验室,300万(实际负责人)
3、温州市级平台项目:温州市生物医药协同创新中心,150万。(主持工作)
4、省部共建:教育部省部共建生物医药协同创新中心。(第二单位参与)
五、指导竞赛获奖
1、浙江省第八届国际互联网+创新创业大赛,银奖
2、浙江省第十三届挑战杯大学生创新创业大赛,银奖
3、2022暑期社会实践活动优秀团队,优秀指导教师,十佳精品,大挑立项。
4、全国第八届互联网+创新创业大赛,铜奖
邮编:325035
E-mail:20160121@wzu.edu.cn