个人简介

孙达，男，博士&副研究员&硕导&生命科学研究院院长助理（生物学学硕 & 药学专硕 两个专业方向招生）。本硕博均在重庆大学完成学业，期间（2014-2015）于中国科学院金属研究所联合培养一年。

现主持科学研究项目5项，累计经费65万，并作为主要人员参与7项科学研究项目。在Theranostics、Materials Science & Engineering C、Pharmaceutics、 Materials Letters、 Environmental Science and Pollution Research等国内外学术刊物上发表论文50篇（累计IF＞180），其中第一/通讯作者论文33篇（累计IF＞130），获授权专利9项，转化1项。

担任Theranostics、Journal of Materials Science & Technology、Science of the Total Environment、Frontiers in Bioscience-Landmark、Heliyon、Biocell等多个国际期刊审稿专家。

主要研究方向

生物医用材料的功能化 及 生物资源开发与利用。
第一^#/通讯*作者：

2022年度

(1) Guoming Zeng#, Yujie Ran#, Xin Huang, Yan Li, Maolan Zhang*, Hui Ding, Yonggang Ma, Hongshuo Ma, Libo Jin, Da Sun*, Optimization of Ultrasonic-Assisted Extraction of Chlorogenic Acid from Tobacco Waste, International Journal of Environmental Research and Public Health, 2022.1.29, 19(3): 1555.（生物学/环境科学，IF=3.39）

(2) Linkai Qu#, Lei Wang#, Hao Ji#, Yimeng Fang, Pengyu Lei, Xingxing Zhang, Libo Jin, Da Sun*, Hao Dong*, Toxic Mechanism and Biological Detoxification of Fumonisins, Toxins, 2022.3.1, 14(3), 182.（生物学，IF=4.546）

(3) Li Zhu, Yuan Zhong, Shuai Wu, Meng Yan, Yu Cao, Nianlian Mou, Guixue Wang, Da Sun*, Wei Wu*, Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics, Materials Today Bio, 2022.3.3, 14: 100228.（生物医学工程/药学，IF=7.348）

(4) Jun Wang#, Guoming Zeng#, Fei Wang, Xin Huang, Yan Li, Dong Liang, Maolan Zhang, Da Sun*, Study on the Algae Lysis Method of White Rot Fungi Algae Control System, Water, 2022.3.14, 14(6): 903.（生物学/环境科学，IF=3.103）

(5) Ji-An You, Yuhan Gong, Yongzhe Wu, Libo Jin, Qingjia Chi*, Da Sun*, WGCNA, LASSO and SVM Algorithm Revealed RAC1 Correlated M0 Macrophage and the Risk Score to Predict the Survival of Hepatocellular Carcinoma Patients, Frontiers in Genetics, 2022.3.18, 12: 730920.（生物学，IF=4.599）

(6) Lei Wang#, Linkai Qu#, Sue Lin, Qinsi Yang, Xingxing Zhang, Libo Jin*, Hao Dong*, Da Sun*, Biological functions and applications of antimicrobial peptides, Current Protein & Peptide Science, 2022.4.07.（生物学，IF=3.272）

(7) Lei Wang#, Jiahui Ma#, Wei Wu#, Yimeng Fang, Fan Liu, Qinsi Yang, Xiang Hu, Xuejiang Gu, Zhiying He, Da Sun*, Libo Jin*, Xingxing Zhang*, Effect of aerobic exercise as a treatment on type 2 diabetes mellitus with depression-like behavior zebrafish, Life Sciences, 2022.4.20.（生物医学工程，IF=5.037）

(8) Quanfeng Wang, Cenhui Liao, Jujiao Zhao*, Guoming Zeng, Wenbo Liu, Pei Gao, Da Sun*, Juan Du, Combined Process of Biogenic Manganese Oxide and Manganese-Oxidizing Microalgae for Improved Diclofenac Removal Performance: Two Different Kinds of Synergistic Effects, Toxics, 2022.4.28.（生物学，IF=4.146）

(9) Maolan Zhang#, Guoming Zeng#, Dong Liang, Yiran Xu, Yan Li, Xin Huang, Yonggang Ma, Fei Wang, Chenhui Liao, Cheng Tang, Hong Li*, Yunzhu Pan*, Da Sun*, An Analysis of the colony structure of prokaryotes in the Jialing River waters in Chongqing, International Journal of Environmental Research and Public Health, 2022.4.29.（生物学/环境科学，IF=3.103）

2021年度

(1) Maolan Zhang, Yuanliang Wang, Guoming Zeng*, Shuang Yang, Xiaoling Liao, Da Sun*, Antibacterial activity and mechanism of piperazine polymer, Journal of Applied Polymer Science, 2021.1.10, 138: e50451.（生物医学工程/药学，IF=3.125）

(2) Libo Jin^#, Guoming Zeng^#, Haojie Chen, Lei Wang, Hao Ji, Sue Lin, Renyi Peng, Da Sun*, Mechanism of Lignin Degradation via White Rot Fungi Explored Using Spectral Analysis and Gas Chromatography-Mass Spectrometry, BioResources, 2021.6.15.（生物学/环境科学，IF=1.614）

(3) Guoming Zeng,Yan Li, Sijie He, Mengyi Lin, Xixian Fu, Longqing Tang, Xuanhao Fan, Yu He, Ximei He, Da Sun*, HCl-CH3COOH MIXED ACID EXTRACTION AND CHARACTERIZATION OF PECTIN FROM TOBACCO STEMS, Fresenius Environmental Bulletin, 2021.4.18.（生物学/环境科学，IF=0.489）

(4) Maolan Zhang, Yan Li, Jiale Wang, Ningbang Shan, Hanyu Li, Xuehua Deng, Da Sun*, POLY (LACTIC ACID) CONTAINING beta - CYCLODEXTRIN: A PROMISING PREPOLYMER FOR THE ADSORPTION OF Cr6+ AND METHYLENE BLUE, Fresenius Environmental Bulletin, 2021.4.25.（生物学/环境科学，IF=0.489）

(5) Hao Ji#, Renyi Peng#, Libo Jin#, Jiahui Ma, Qinsi Yang, Da Sun*, Wei Wu*, Recent Advances in ROS-Sensitive Nano-Formulations for Atherosclerosis Applications, Pharmaceutics, 2021.9.9. 13(9), 1452.（生物医学工程/药学，IF=6.321）

(6) Yaoqi Li#, Da Sun#, Ke Xu*, Libo Jin*, Renyi Peng*, Hydrogen Sulfide Enhances Plant Tolerance to Waterlogging Stress, Plants, 2021.9.16. 10(9), 1928.（生物学，IF=3.935）

(7) Xu Rui, Qibiao Wu, Qingjia Chi*, Da Sun*, A novel prognostic target-gene signature and nomogram based on an integrated bioinformatics analysis in hepatocellular carcinoma, Biocell, 2021.9.24.（生物学，IF=1.254）

(8) Haojie Chen#, Hao Ji#, Xiangjun Kong, Pengyu Lei, Qinsi Yang, Wei Wu, Libo Jin*, Da Sun*, Bacterial Ghosts-Based Vaccine and Drug Delivery Systems, Pharmaceutics, 2021.11.2. 13(11), 1892.（生物医学工程/药学，IF=6.321）

2020年度

(1) Renyi Peng^#, Hao Ji^#, Libo Jin^#, ..., Da Sun^*, Wei Wu^*, et al., Macrophage-Based Therapies for Atherosclerosis Management, Journal of Immunology Research, 2020.01, 8131754（生物医学工程/药学，IF=4.818）

(2) Kun Zhang^#, Da Sun^#*, Chuanren Duan^#*, et al., Application of a Faecalibacterium 16S rDNA genetic marker for species identification of dog fecal waste, Environmental Science and Pollution Research, 2020.5.29. 27: 30615-30624（生物学/环境科学，IF=4.223）

(3) Guoming Zeng^#, Maolan Zhang^#, Pei Gao, Jiale Wang, Da Sun*, Algicidal efficiency and genotoxic effects of Phanerochaete chrysosporium against Microcystis aeruginosa, International Journal of Environmental Research and Public Health, 2020.5.30, 17(11): 4029（生物学/环境科学，IF=3.39）

(4) Guoming Zeng, Pei Gao, Jiale Wang, Jinxi Zhang, Maolan Zhang*, Da Sun*, Molecular algicidal mechanism and toxicological degradation of Microcystis aeruginosa by white rot fungi, Toxins, 2020.6.18, 12(6): 406（生物学/环境科学，IF=4.546）

(5) Guoming Zeng^#, Libo Jin^#, Qinsi Ying, Haojie Chen, Murinda Charmaine Thembinkosi, Chunguang Yang, Jinlong Zhao, Hao Ji, Sue Lin, Renyi Peng, Maolan Zhang*, Da Sun*, Regulatory T cells in cancer immunotherapy: basic research outcomes and clinical directions, Cancer Management and Research, 2020.10.21, 12: 10411-10421.（生物医学工程/药学，IF=3.989）

2019年度

(1) Da Sun^#*, Jia Chen^#, Wei Wu^#, Ju Tang, Li Luo, Kun Zhang, Libo Jin, Sue Lin, Yitian Gao, Xiaoqing Yan, Chi Zhang, MiR‐802 causes nephropathy by suppressing NF‐κB‐repressing factor in obese mice and human, Journal of Cellular and Molecular Medicine, 2019.02.07, 23(4): 2863-2871（生物医学工程/药学，IF=5.31）

(2) D. Sun*, J. Chen, H. Hu, et al., Acanthopanax senticosus polysaccharide suppressing proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells is associated with Wnt/β-catenin signaling, Neoplasma, 2019.7.29, 66(4): 555-563（生物医学工程/药学，IF=2.575）

(3) Libo Jin^#, J. Chen^#, ..., Da Sun*, Tripterygium wilfordii polyglycosides inhibit TGF-beta 1/nf-kappa b signaling pathway and improve renal fibrosis in diabetic nephropathy, Acta Medica Mediterranea, 2019.2.20, 35: 2787-2791（生物医学工程/药学，IF=0.219）

(4) Da Sun^#, Jia Chen^#, Yuan Wang, Hao Ji, Renyi Peng, Libo Jin*, Wei Wu*, Advances in refunctionalization of erythrocyte-based nanomedicine for enhancing cancer-targeted drug delivery, Theranostics, 2019.9.21, 9(23): 6885-6900（生物医学工程/药学，IF=11.556）

2018年度

(1) Li Luo^#, Wei Wu^#, Da Sun^#, et al., Acid-activated melittin for targeted and safe antitumor therapy, Bioconjugate Chemistry, 2018, 29(9): 2936-2944（生物医学工程/药学，IF=4.774）

2017年度
(1) Da Sun^#, Kun Zhang^#, Chuanren Duan^#*, Wei Wu, Daiyong Deng, Donghong Yu, M. Babar Shahzad, Dake Xu, Ju Tang, Li Luo, Jia Chen, Jinxuan Wang, Yidan Chen, Xiang Xie, Guixue Wang*, Potential application of an Aspergillus strain in a pilot biofilter for benzene biodegradation, Scientific Reports, 2017, 7(1): 46059（生物学/环境科学，IF=4.38）

(2) Wei Wu^#, Jia Chen^#, Da Sun^#*, Xiangjun Kong, Dake Xu, Yi Wang, Li Luo, Kun Zhang, Keshen Xiao*, Guixue Wang*, Study on antibacterial performance and biocompatibility of a novel phosphorus-magnesium fiber. Materials Letters, 2017.12.15, 209: 562-565（生物医学工程/药学，IF=3.423）

2016年度

(1) Da Sun^#, Dake Xu^#, Chunguang Yang, et al., Inhibition of Staphylococcus aureus biofilm by a copper-bearing 317L-Cu stainless steel and its corrosion resistance, Materials Science & Engineering C-Materials for Biological Applications, 2016.12.1, 69: 744-750（生物医学工程，IF=7.328）
(2) Da Sun^#, Dake Xu^#, Chunguang Yang, et al., An investigation of the antibacterial ability and cytotoxicity of a novel cu-bearing 317L stainless steel, Scientific Reports, 2016.7.7, 29244（生物医学工程，IF=4.38）
(3) Da Sun^#, Chuanren Duan^#*, Yaning Shang, Yunxia Ma, Lili Tan, Jun Zhai, Xu Gao, Jingsong Guo, Guixue Wang*, Application of Faecalibacterium 16S rDNA genetic marker for accurate identification of duck faeces, Environmental Science and Pollution Research, 2016.4.01, 23(8): 7639-7647（生物学/环境科学，IF=4.223）

2015年度

(1) D. Sun^#, Shahzad M. Babar^#, M.Li, et al., Antimicrobial materials with medical applications, Materials Technology, 2015.5.01, 30(B2): B90-B95（生物医学工程，IF=3.846）

 

其他论文：

(1) 成功桥饮用水水库污染特征分析及对策探讨，2011年环境污染与大众健康学术会议，2011.09.30, 1106–1109, 1/8;

(2) 白腐菌木质素降解酶及其在木质素降解过程中的相互作用，生物技术通报，2011.10.26，(10): 32–36, 4/5;

(3) 1株甲苯降解真菌的筛选鉴定及其降解甲苯的特性，微生物学杂志，2011.5.15, (03): 41~47, 6/6;
(4) 应用Faecalibacterium菌示踪水环境粪便污染研究进展，应用与环境生物学报，2013.12.25, (06): 1073–1078, 7/8;
(5) Laboratory investigation of the microbiologically influenced corrosion (MIC) resistance of a novel Cu-bearing 2205 duplex stainless steel in the presence of an aerobic marine Pseudomonas aeruginosa biofilm, Biofouling, 2015.01.01, 31(6): 481–492, 4/9;

(6) Evaluation of Faecalibacterium 16S rDNA genetic markers for accurate identification of swine faecal waste by quantitative PCR, Journal of Environmental Management, 2016.10.1, 181：193–200，7/8;

(7) 基于专利数据的血管内支架研究发展趋势分析，北京生物医学工程，2017.06.16, (03): 290–297, 4/8;

(8) Shear stress-mediated angiogenesis through id1 relevant to atherosclerosis, Molecular & Cellular Biomechanics, 2017, 14(2): 83–100, 9/12;

(9) Dual tumor-targeted poly(lactic-co-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery, International Journal of Nanomedicine, 2017.7.18, 12: 5745–5760, 7/10;

(10) Genotoxicity effects of Phanerochaete chrysosporium against harmful algal bloom species by micronucleus test and comet assay, Chemosphere, 2018.11.24, 218: 1031–1041, 6/6;

(11) Antibacterial durability and biocompatibility of antibacterial-passivated 316L stainless steel in simulated physiological environment, Materials Science & Engineering C-Materials for Biological Applications, 2019.3.8, 100: 396–410, 3/8;

(12) Comprehensive analysis of Ogura cytoplasmic male sterility-related genes in turnip (Brassica rapa ssp. rapifera) using RNA sequencing analysis and bioinformatics, Plos One, 2019.6.14, 14(6):e0218029, 6/9;

(13) Interleukin‐1β augments the angiogenesis of endothelial progenitor cells in an NF‐κB/CXCR7‐dependent manner, Journal of Cellular and Molecular Medicine, 2020.4.2, 8/16;

(14) Identification of new dermaseptins with self-assembly tendency: membrane disruption, biofilm eradication, and infected wound healing efficacy, Acta Biomaterialia, 2020.4.9, 5/11；

(15) Transcriptional profiling reveals molecular basis and the role of arginine in response to low-pH stress in Pichia kudriavzevii, Journal of Bioscience and Bioengineering, 2020.7.17, 4/8;

(16) Intelligent deformation of biomedical polyurethane, Frontiers of Materials Science, 2021.1.21, 4/5;

(17) FGF21 Promotes Ischemic Angiogenesis and Endothelial Progenitor Cells Function under Diabetic Conditions in an AMPK/NAD+-Dependent Manner, Journal of Cellular and Molecular Medicine, 2021.2.17, 11/20；

(18) Pretreatment technology of lignocellulose, 第二届可持续发展与能源科技国际学术会议（ICSE 2021）, 2021.3.17, 3/7。

(19) Sequential Production of ᴅ-xylonate and Ethanol from Non-Detoxified Corncob at Low-pH by Pichia kudriavzevii via a Two-Stage Fermentation Strategy, Journal of Fungi, 2021.12.1, 4/5.

(20) Study on ionic liquid treatment and enzymatic hydrolysis of corn stover after activation of zinc chloride solution, 2021 第五届绿色复合材料与纳米技术国际会议 (GCMN 2021), Journal of Physics: Conference Series, 2021.7.23, 4/5.

 

授权专利：
(1) 孙达，等，一种生物滤塔，实用新型，ZL201220018146.5；
(2) 段传人，崔亚敏，张坤，孙达，等，一种含有PFB-1引物对的猪粪便污染检测试剂盒及其制备与应用，发明专利，ZL201610036898.7；(已转化，http://kjc.cqu.edu.cn/info/1024/4935.htm)
(3) 段传人，崔亚敏，张坤，孙达，等，一种含有PFB-2引物对的猪粪便污染检测试剂盒及其制备与应用，发明专利，ZL201610037363.1；

(4) 孙达，等，一种实验用白腐真菌控藻装置，实用新型，ZL201821574235.1；
(5) 孙达，等，试管清洗装置，实用新型，ZL201822114229.4；

(6) 金立波，孙达，等，康复行走训练医用拐杖，实用新型，ZL201822169717.5；

(7) 金立波，尹海燕，孙达，等，一种新型医学检验管，实用新型，ZL201821596956.2；

(8) 金立波，彭仁义，孙达，等，基于药用植物材料来源的粉末和药机，发明专利，ZL201910039638.9。

(9) 孙达，金立波，杨秦斯，嵇豪，林苏娥，彭仁义，等，一种空气过滤结构层、空气净化器、口罩，实用新型，ZL202020279233.0。

主持课题：
(1) 浙江省药学重中之重一级学科开放基金，成纤维细胞生长因子系列蛋白表达及关键工程化技术研究，201720，2017-2019，6万；

(2) 温州市水污染控制与治理科技创新项目，利用食用型白腐真菌进行水体控藻的研究，W20170010，2017-2020，20万；

(3) 浙江省自然科学基金青年项目，317L含铜不锈钢在糖尿病足领域的应用研究，Q19E010021，2019-2021，10万；

(4) 国家自然科学基金青年项目，一种适用糖尿病患者的新型血管支架材料的生物学效应研究，51901160，2020-2022，26万；

(5) 温州市科技局基础性科研项目，生物质耦合白腐菌强化治理蓝藻水华代谢损伤机制及生物毒理性研究，S2020005，2020-2022，3万。

参与课题：
(1) 2014/01-2017/12，国家自然科学基金面上项目，31370949，高切应力促进血管新生介导易损斑块形成的力生物学机制，82万，6/10；

(2) 2017/01-2019/12，国家自然科学基金青年项目，51603023，血小板膜包被仿生纳米前药用于高效靶向抑制血管再狭窄的研究，20万，2/6；
(3) 2017/08-2018/12，温州市科技计划项目，2017N0015，一氧化氮（NO）提升水涝灾害后玉米幼苗成活率的研究，3万，3/6；
(4) 2019/01-2020/12，温州市科技计划项目，2018G0178，多耐受酵母Pichia kudriavzevii低pH发酵生产D-木糖酸的关键技术研究，5万，3/5；

(5) 2019/01-2021/12，国家自然科学基金青年项目，81803590，靶向优化的新型抗菌肽MS-PT1a抗耐甲氧西林金黄色葡萄球菌的作用与机制研究，21万，4/7；

(6) 2020/01-2023/12，国家自然科学基金面上项目，31972418，白菜花粉响应低温胁迫的lncRNA-BrCBF4-COR基因调控通路研究，58万，5/10；

(7) 2020/01-2021/12，温州市科技计划项目，N20190006，番鸭细小病毒非结构蛋白NS2诱导鸭胚成纤维细胞凋亡的分子机制研究，6万，3/4；

(8) 省级平台项目：浙江省生物医药协同创新中心，500万，4/6；

(9) 省级平台项目：生长因子药物开发浙江省工程实验室，300万，4/4；

(10) 市级平台项目：温州市生物医药协同创新中心，150万，4/7.

联系方式: sunday@wzu.edu.cn； ORCID: https://orcid.org/0000-0001-7747-9951